APL-130277 Published Data

MOVEMENT DISORDERS SOCIETY 20th INTERNATIONAL CONGRESS OF PARKINSON'S DISEASE AND MOVEMENT DISORDERS 2016 - BERLIN, GERMANY, JUNE 19-23, 2016

Disease Severity is Not Predictive of the Dose Required for Apomorphine Sublingual Film (APL-130277) to Convert a Patient with Parkinson's Disease from OFF to Fully ON
Holly Shill, MD, Eric J. Pappert, MD, Albert Agro, PhD, Bruce Dzyngel, BSc (Hons), Thierry Bilbault, PhD, Stuart Isaacson, MD, Robert A. Hauser, MD

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Treatment of OFF Episodes in Parkinson's Disease: An Evaluation of Patient and Caregiver Insights
Eric J. Pappert, MD, Nigel deGruyther, B.Sc.Pharm, MBA, Albert Agro, PhD

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Treatment of OFF Episodes in Parkinson's Disease: An Evaluation of Physician Insights
Eric J. Pappert, MD, Albert Agro, PhD, Nigel deGruyther, B.Sc.Pharm, MBA

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Oral Apomorphine Film (APL-130277) Produces No Buccal Mucosal Irritation: Results from a 28-Day Toxicology Study in Hamsters
Albert Agro, PhD, Eric J. Pappert, MD, Bruce Dzyngel, BSc (Hons), Thierry Bilbault, PhD, Simon Taylor, BSc, Robin Walker, PhD

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The Efficacy of Apomorphine Sublingual Film (APL-130277) to Turn a Patient with Parkinson's Disease from an OFF State to a Full ON State by Demographics and Baseline Characteristics
Holly Shill, MD, Eric J. Pappert, MD, Albert Agro, PhD, Bruce Dzyngel, BSc (Hons), Thierry Bilbault, PhD, Robert A. Hauser, MD, Stuart Isaacson, MD

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Pharmacokinetic-Pharmacodynamic Effects of Apomorphine Sublingual Film (APL-130277) for the Rapid Management of OFF Episodes in Patients with Parkinson's Disease
Eric J. Pappert, MD, Bruce Dzyngel, BSc (Hons), Thierry Bilbault, PhD, Albert Agro, PhD

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Minimum MDS-UPDRS Part III Change Needed to Convert a Patient with Parkinson's Disease from the OFF to Full ON State with Apomorphine Sublingual Film (APL-130277)
Holly Shill, MD, Eric J. Pappert, MD, Bruce Dzyngel, BSc (Hons), Albert Agro, PhD, Thierry Bilbault, PhD, Stuart Isaacson, MD, Robert A. Hauser, MD

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EUROPEAN ACADEMY OF NEUROLOGY 2ND CONGRESS – COPENHAGEN, DENMARK, MAY 28-31 2016

The Treatment of OFF Episodes in Parkinson’s Disease: An Evaluation of Patient and Caregiver Insights
Eric J. Pappert, MD, Nigel deGruyther, BScPharm, MBA, Albert Agro, PhD

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The Treatment of OFF Episodes in Parkinson’s Disease: An Evaluation of Physician Practices
Eric J. Pappert, MD, Albert Agro, PhD, Nigel deGruyther, BScPharm, MBA

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Apomorphine Film (APL-130277) Produces No Buccal Mucosal Irritation: Results from a 28-Day Toxicology Study in Hamsters
Eric J. Pappert, MD, Bruce Dyzngel, Thierry Bilbault, PhD, Albert Agro, PhD, Simon Taylor, PhD, Robin Walker, PhD

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AMERICAN ACADEMY OF NEUROLOGY 68TH ANNUAL MEETING - VANCOUVER CANADA APRIL 15-21 2016

Efficacy of Sublingual Apomorphine Film Strip (APL-130277) for the Treatment of OFF Episodes in Patients with Parkinson's Disease
Robert Hauser, Bruce Dzyngel, Thierry Bilbault, PhD, Holly Shill, MD, Albert Agro, PhD

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Safety of Sublingual Apomorphine (APL-130277) for the Treatment of OFF Episodes in Patients with Parkinson's disease
Stuart Isaacson, MD, Eric J. Pappert, MD, Bruce Dzyngel, Thierry Bilbault, PhD, Albert Agro, PhD

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The Effects of Sublingual Apomorphine (APL-130277) by Disease Severity on the Acute Management of OFF Episodes in Parkinson's Disease
Holly Shill, MD, Eric J. Pappert, MD, Bruce Dzyngel, Thierry Bilbault, PhD, Albert Agro, PhD

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XXI WORLD CONGRESS ON PARKINSONS DISEASE AND RELATED DISORDERS - MILAN, ITALY, DECEMBER 6-9, 2015

Efficacy of sublingual apomorphine film strip (APL-130277) for the treatment of OFF episodes in patients with Parkinson's disease
Stuart Isaacson, MD, Albert Agro, PhD, Jordan Dubow, MD Bruce Dzyngel, Thierry Bilbault, PhD, Anthony Giovinazzo, Holly Shill, MD, Robert A. Hauser, MD

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Safety of sublingual apomorphine (APL-130277) for the treatment of OFF episodes in patients with Parkinson's disease
Albert Agro, PhD, Jordan Dubow, MD, Bruce Dzyngel Thierry Bilbault, PhD, Anthony Giovinazzo, Stuart Isaacson, MD

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The effects of sublingual apomorphine (APL-130277) by disease characteristics on the acute management of OFF episodes in Parkinson’s disease
Jordan Dubow, MD, Bruce Dzyngel, Thierry Bilbault, PhD, Anthony Giovinazzo, Albert Agro, PhD

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Baseline disease severity not predictive of sublingual apomorphine (APL-130277) dose needed to convert a PD patient from the OFF to ON state
Jordan Dubow, MD, Bruce Dzyngel, Thierry Bilbault, PhD, Anthony Giovinazzo, Albert Agro, PhD

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Minimum MDS-UPDRS Part III change needed to convert a Parkinson’s disease patient from the OFF to full ON state with sublingual apomorphine (APL-130277)
Jordan Dubow, MD, Bruce Dzyngel, Thierry Bilbault, PhD, Anthony Giovinazzo, Albert Agro, PhD

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AMERICAN NEUROLOGICAL ASSOCIATION 140th ANNUAL MEETING - CHICAGO, IL, SEPTEMBER 27-29, 2015

Pharmacokinetics, safety and tolerability of sub-lingually administered APL-130277 compared to subcutaneous apomorphine in healthy volunteers
Albert Agro, PhD, Jordan Dubow, MD, Lee Toong-Chow, PhD and Anthony Giovinazzo (Abstract S402). Annals of Neurology. 2015;78(Issue S19):S44.

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Efficacy of sublingual apomorphine (APL-130277) for the treatment of OFF episodes in patients with Parkinson's disease
Robert A Hauser, MD, Jordan Dubow, MD, Bruce Dzyngel, Thierry Bilbault, PhD, Anthony Giovinazzo and Albert Agro, PhD (Abstract S403): Annals of Neurology. 2015;78(Issue S19):S44.

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Safety of sublingual apomorphine (APL-130277) for the treatment of OFF episodes in patients with Parkinson's disease
Stuart Isaacson, MD, Jordan Dubow, MD, Bruce Dzyngel, Thierry Bilbault, PhD, Anthony Giovinazzo and Albert Agro, PhD (Abstract S415). Annals of Neurology. 2015;78(Issue S19):S47.

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Pharmacokinetic-Pharmacodynamic effects of sublingual apomorphine (APL-130277) for acute rescue of OFF episodes in Parkinson’s disease patients
Jordan Dubow, MD; Bruce Dzyngel; Thierry Bilbault, PhD; Anthony Giovinazzo; Albert Agro, PhD (Abstract S416). Annals of Neurology. 2015;78(Issue S19):S48-49.

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Pharmacokinetic-pharmacodynamic Effects of Sublingual Apomorphine (APL-130277) for the Acute Management of OFF Episodes in Parkinson’s Disease Patients
Jordan Dubow, MD; Bruce Dzyngel; Thierry Bilbault, PhD; Anthony Giovinazzo; Albert Agro, PhD

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EUROPEAN ACADEMY OF NEUROLOGY 1ST CONGRESS - BERLIN, GERMANY, JUNE 20-23 2015

Efficacy of sublingual apomorphine (APL-130277) for the treatment of OFF episodes in patients with Parkinson's disease
Robert A Hauser, MD, Jordan Dubow, MD, Bruce Dzyngel, Thierry Bilbault, PhD, Anthony Giovinazzo and Albert Agro, PhD (Abstract P2153). European Journal of Neurology. 2015;22(Suppl 1):249.

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Safety of sublingual APL-130277 for the treatment of OFF episodes in patients with Parkinson's disease
Stuart Isaacson, MD, Jordan Dubow, MD, Bruce Dzyngel, Thierry Bilbault, PhD, Anthony Giovinazzo and Albert Agro, PhD (Abstract P2154). European Journal of Neurology. 2015;22(Suppl 1):250.

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MOVEMENT DISORDERS SOCIETY 19TH INTERNATIONAL CONGRESS OF PARKINSON’S DISEASE AND MOVEMENT DISORDERS 2015 – SAN DIEGO, CA, JUNE 14-18, 2015

Pharmacokinetics, safety and tolerability of sub-lingually administered APL-130277 compared to subcutaneous apomorphine in healthy volunteers
Albert Agro, PhD, Jordan Dubow, MD, Lee Toong-Chow, PhD and Anthony Giovinazzo (Abstract #170). Movement Disorders. 2015;30(Suppl 1):S64-65.

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Pharmacokinetics, safety and tolerability of high-dose sub-lingually administered APL-130277 in healthy volunteers
Albert Agro, PhD, Jordan Dubow, MD, Lee Toong-Chow, PhD and Anthony Giovinazzo (Abstract #171). Movement Disorders. 2015;30(Suppl 1):S65-66.

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Efficacy of sublingual apomorphine (APL-130277) for the treatment of OFF episodes in patients with Parkinson's disease
Robert A Hauser, MD, Jordan Dubow, MD, Bruce Dzyngel, Thierry Bilbault, PhD, Anthony Giovinazzo and Albert Agro, PhD (Abstract #233). Movement Disorders. 2015;30(Suppl 1):S90.

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Safety of sublingual APL-130277 for the treatment of OFF episodes in patients with Parkinson's disease
Stuart Isaacson, MD, Jordan Dubow, MD, Bruce Dzyngel, Thierry Bilbault, PhD, Anthony Giovinazzo and Albert Agro, PhD (Abstract #243). Movement Disorders. 2015;30(Suppl 1):S94-95.

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AMERICAN ACADEMY OF NEUROLOGY 67TH ANNUAL MEETING – WASHINGTON, DC, APRIL 18-25, 2015

Pharmacokinetic-Pharmacodynamic Effects of Sublingual Apomorphine (APL-130277) for Acute Rescue of OFF Episodes in Parkinson’s Disease Patients
Jordan Dubow, MD; Bruce Dzyngel; Thierry Bilbault, PhD; Anthony Giovinazzo; Albert Agro, PhD

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